Fluorescent Nitrogen Doped Carbon Dots: Prospect for Applications in Biological Systems
160,000
Completed
University of Dhaka
Start: July 1, 2024
End: June 30, 2025
Abstract
Fluorescent Nitrogen-Doped Carbon Dots (N-CDs) are emerging as a transformative class of biocompatible, zero-dimensional nanomaterials (
nm) with significant prospects in biological systems. By incorporating nitrogen into the carbon core, these dots exhibit enhanced fluorescence, higher quantum yields, and improved water solubility, making them superior alternatives to traditional organic dyes and semiconductor quantum dots in biomedical applications.
Key Advantages for Biological Systems
Biocompatibility and Low Toxicity: N-CDs derived from natural sources (e.g., tea, starch, agricultural waste) exhibit minimal cytotoxicity, with studies showing cell viability above 85–90% even at high concentrations.
Photostability: Unlike organic dyes that fade, N-CDs are resistant to photobleaching and photo-degradation, enabling long-term tracking in live cells.
Upconversion Photoluminescence: N-CDs can absorb long-wavelength (visible/near-infrared) light and emit shorter wavelengths, which reduces autofluorescence and allows for deeper tissue penetration during imaging.
nm) with significant prospects in biological systems. By incorporating nitrogen into the carbon core, these dots exhibit enhanced fluorescence, higher quantum yields, and improved water solubility, making them superior alternatives to traditional organic dyes and semiconductor quantum dots in biomedical applications.
Key Advantages for Biological Systems
Biocompatibility and Low Toxicity: N-CDs derived from natural sources (e.g., tea, starch, agricultural waste) exhibit minimal cytotoxicity, with studies showing cell viability above 85–90% even at high concentrations.
Photostability: Unlike organic dyes that fade, N-CDs are resistant to photobleaching and photo-degradation, enabling long-term tracking in live cells.
Upconversion Photoluminescence: N-CDs can absorb long-wavelength (visible/near-infrared) light and emit shorter wavelengths, which reduces autofluorescence and allows for deeper tissue penetration during imaging.
